M. Varenna

Why do bisphosphonates work in the treatment of CRPS? A translational pharmacological perspective to solve a conundrum

INTRODUCTION: Bisphosphonates (BPs) have consistently yielded positive results in the treatment of Complex Regional Pain Syndrome (CRPS). However, biochemical and histopathological evidence suggests that osteoclasts, the primary pharmacological target of BPs, is not a key driver...