M. Macchi

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

BACKGROUND: The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. OBJECTIVE: To perform an integrative multi-omics reanalysis of single-cell transcriptomic and epigenomic data to identify convergent alte...