Lydia Nakiyingi

Empiric tuberculosis treatment and 12-month mortality among sputum GeneXpert-negative adults living with HIV in Uganda in the era of widespread antiretroviral therapy: A prospective cohort study

Abstract Background In sub-Saharan Africa where both tuberculosis (TB) and HIV are prevalent, empiric TB treatment in people living with HIV (PLHIV) persists due to limited sensitivity of sputum-based TB tests. We evaluated mortality among molecular test-negative presumptive TB a...

Time to sputum culture conversion and associated factors among rifampicin-resistant pulmonary tuberculosis patients treated with Bedaquiline at Mulago hospital, Uganda

Sputum culture conversion in patients with pulmonary tuberculosis (PTB) is the most important interim indicator for drug-resistant (DR) tuberculosis (TB) treatment effectiveness. Bedaquiline-based regimens offer the possibility of more effective and less toxic treatment for DR TB...

Integrated in silico assessment of the regulatory and structural consequences of pulmonary tuberculosis-associated SP110 polymorphisms

Abstract The molecular mechanisms underlying conflicting findings of association of SP110 single nucleotide polymorphisms (SNPs) with susceptibility to pulmonary tuberculosis (PTB) remain unclear. We selected ten SP110 SNPs from publicly available genomic databases, based on prio...