Lutz Ackermann

MnBn(CO)5-Catalyzed Cascade C–H Activation/Annulation to Construct Bridged N -Heterocycles

Abstract Herein, a manganese-catalyzed synthesis of bridged heterocycles via a C–H activation/annulation cascade between azomethine imines and Morita–Baylis–Hillman adducts is described. MnBn(CO)5 serves as a highly active catalyst, exhibiting unique and remarkable capability in...

Transient-Directing Group-Enabled Manganese-Catalyzed C–H Alkylation

Abstract The construction of C–C bonds by manganese-catalyzed C–H activation thus far relies on permanent directing groups that need to be installed and removed, while the use of transient directing groups remains an elusive challenge. In sharp contrast, we herein describe a mang...

Modular Access to α ‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

ABSTRACT Quaternary carbon centers, especially those bearing nitrogen, are highly valued in drug discovery, imparting three‐dimensionality, selectivity, and metabolic stability. Yet, accessing α ‐tertiary, primary amines ( α ‐TPAs) remains challenging due to steric congestion and...