Luo Zhang

The “Five in One” integrated precise prevention and control system for pollen allergic diseases in Northern China: A narrative review with global perspective

Allergic diseases driven by airborne pollen are a growing public health burden in Northern China, where spring tree pollens and summer–autumn weed pollens are major triggers of allergic rhinitis, asthma, conjunctivitis, atopic dermatitis, and anaphylaxis. Internationally, managem...

Stapokibart efficacy by asthma status in chronic rhinosinusitis with nasal polyps: a post hoc analysis of the CROWNS-2 trial

Background: Asthma is a common comorbidity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Stapokibart, a novel anti-interleukin-4 receptor alpha monoclonal antibody, demonstrated efficacy and safety in patients with CRSwNP in a phase 3 trial (NCT05436275). Ob...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...