Luke M. Healy

A validated antibody toolbox for ALS research

A substantial fraction of amyotrophic lateral sclerosis (ALS)-associated proteins remains poorly characterized, in part because of the limited availability of validated research antibodies. We established knockout (KO)-based antibody characterization workflows and demonstrated th...

Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins

In Alzheimer’s disease (AD), activation of the mechanistic target of rapamycin (mTOR) pathway promotes microglial neuroprotective functions by engaging multiple cell receptors. However, the relevant downstream effectors are not fully understood. mTOR complex 1 (mTORC1) promotes m...