Łukasz Struk

Liposomal Formulations Containing Amino Acid Menthol Ester Naproxenate: Physicochemical Characterization and Transdermal Delivery Potential

Non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, are widely used for the treatment of pain and inflammation; however, their therapeutic application is limited by poor aqueous solubility and low bioavailability. This study aimed to synthesize and characterize a...

Drug-based ionic derivatives of NSAIDs: influence of cation structure on physicochemical properties, skin permeation, and biocompatibility

Abstract Drug-based ionic systems represent a promising strategy to improve the physicochemical properties and delivery performance of poorly soluble active pharmaceutical ingredients. In this study, ionic derivatives of four nonsteroidal anti-inflammatory drugs (NSAIDs)—ibuprofe...