Luca Spagnolo

Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents

Importance Puberty is a critical window for bone mass acquisition, determining lifelong fracture risk. Gonadotropin-releasing hormone agonist (GnRHa)–based pubertal suppression followed by gender-affirming hormone therapy (GAHT) is increasingly used in transgender and gender-dive...