Luc-Alban Vuillemenot

WEE1 opposes APC/CCDH1 activity to promote S phase entry

Abstract WEE1 phosphorylates and inhibits the activity of cyclin-dependent kinases to prevent mitotic entry and establish a G2 DNA damage checkpoint 1–3 . Consequently, WEE1 inhibitors have been developed to be synthetically lethal in TP53- mutated tumours that become reliant on...