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SIRT2-mediated deacetylation of ANT3 at Lys96 promotes cell death

Abstract ANT3 is a key molecule that constitutes the mitochondrial permeability transition pore (mPTP) and mediates cell death. Disruption or conformational changes in ANT3 protein homeostasis can trigger cell death. However, the molecular mechanism of ANT3 protein homeostasis re...

Spermidine attenuates copper overload-induced cuproptosis in porcine granulosa cells through the miR-194a-5p/DLAT axis

Abstract Excess copper disrupts mitochondrial metabolism by triggering cuproptosis, a regulated cell-death program characterized by the aggregation of lipoylated tricarboxylic acid cycle proteins and the loss of Fe-S cluster proteins. This mitochondrial injury may be particularly...