Louisa von Kohout

From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease

The SARS-CoV-2 main protease (Mpro) is a key antiviral drug target due to its essential role in the pathogen's replication cycle. The development of potent next-generation Mpro inhibitors is of great importance to ensure the availability of safe and effective COVID-19 therapeutic...