Liu Ye

Endoplasmic reticulum stress promotes ferroptosis in ventilator-induced lung injury by promoting HRD1-dependent GPX4 ubiquitination via the IRE1α/XBP1 pathway

Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation. Endoplasmic reticulum stress (ERS) has been implicated in regulating ferroptosis, and we previously linked ERS to VILI-associated inflammation. However, how ERS mechanistically drives ferro...

Perioperative stress–inflammation–immunosuppression axis and tumor progression: mechanistic integration and anesthetic management strategies

Abstract Perioperative stress is an unavoidable part of surgery and may be particularly relevant in patients with cancer. Surgical trauma activates two major stress pathways, the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system (SNS), leading to surges...