Liu W

Visible-Light-Catalyzed In Situ Generation of Nitrile Oxides from Aryl Trichloromethane and TBN for [3 + 2] Cycloaddition to Access Isoxazoline/Isoxazole Scaffolds

Abstract A facile, photochemical three-component protocol for the regioselective synthesis of isoxazolines has been developed using commercially available aryl trichloromethane, alkene, and tert-butyl nitrite as starting materials. Unlike conventional methods that require presynt...

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

ABSTRACT Antibody junctional diversity in jawed vertebrates arose from RAG transposon domestication, generating CDR3‐focused V(D)J recombination with lymphocyte specificity—a constrained system limiting engineered antibody diversity. To overcome these limitations, we developed AR...

Unpacking the complexity of contraceptive use among Chinese university students 2014-2024: a systematic review and meta-analysis.

High risks of unintended pregnancies and abortion have been reported among Chinese university students; however, their contraceptive use remains poorly understood. This study synthesised Chinese university students' contraceptive usage to inform the development of context-specifi...

A pilot prospective study of tislelizumab and axitinib combined with stereotactic body radiation therapy for oligometastatic renal cell carcinoma

<title>Abstract</title> Background The aim of this study is to investigate the efficacy and safety of tislelizumab and axitinib combined with SBRT in the treatment of omRCC. Methods Eligible pts had oligometastases (≤ 5 leisions) and ≤ 1 prior systemic therapy. All patients recei...