Lirong Guo

Human testis-specific TTRP regulates circadian clock as an evolutionarily young natural antisense transcript of PER2

The circadian clock orchestrates a variety of physiological and behavioral processes, endowing the ability to adapt to the cycling environment. Here, we report the identification of TTRP, a TDP-43 pseudogene that emerged in higher Hominoidea species ~8.6 Mya. TTRP is a human test...