Liquan Hong

A Bridge From the Gut: Azithromycin Links to AMPK/SIRT1 Activation, Rectifies Th17/Treg Balance and Alleviates COPD Associated With Gut Microbiota-TMAO Modulation

Background: The intestinal microbial ecosystem has emerged as an important contributor to chronic obstructive pulmonary disease (COPD) pathogenesis. Azithromycin (AZI), a commonly used therapeutic agent for COPD, has antibacterial and anti-inflammatory effects. This study aims to...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...