Linwan Song

Drugging the “undruggable” p53: a structure-guided strategy against the Y220C mutation

Abstract Tumor Protein p53 (TP53 ) is the most frequently altered gene in human cancer, yet mutant p53 has long been considered undruggable. The Y220C mutation is exceptional because it both destabilizes the p53 DNA-binding domain (DBD) and creates a unique surface pocket absent...