Ling Zhang

Nuclear NAD + promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation

Trained immunity is tightly regulated by metabolic and epigenetic reprogramming, yet how these changes are orchestrated at the chromatin level to establish long-term innate immune memory is not fully understood. Here, we show that induction of trained immunity elevates nuclear le...

hsa_circ_0001512 orchestrates endothelial dysfunction in obstructive sleep apnea by regulating the miR-4728-3p/MST4/ERK axis

Abstract Background Cardiovascular complications of obstructive sleep apnea (OSA) show marked vascular endotype heterogeneity that is not fully captured by the apnea-hypopnea index. We tested whether hsa_circ_0001512 acts as an intermittent hypoxia (IH)-responsive circRNA node th...