Ling-fa Xue

Targeting the Thy-1 mechanotransduction regulator rescues regenerative wound healing and induces hair follicle neogenesis under high tension

Abstract Mechanical tension is a critical driver of hypertrophic scar (HS) formation, primarily by inducing the differentiation of fibroblasts into pathological myofibroblasts. However, the upstream mechanotransduction regulators that initiate this fibrotic cell fate switch remai...