Liliana R. Ernandez

An ER retention motif controls the heteromeric stoichiometry of hERG1a/1b channels

Abstract The human ether-à-go-go related gene ( hERG ) encodes a potassium channel essential for cardiac repolarization and neuronal excitability. In the heart, heteromeric assemblies of hERG1a and hERG1b subunits produce cardiac I Kr , and mutations in either subunit are associa...