Li‐Li Zhu

Brønsted Acid‐Catalyzed Tandem Aldol Condensation/1,4‐Aza‐Michael Addition: N 2 ‐Selective Alkylation of Tetrazoles

Herein, we disclose a Brønsted acid‐catalyzed tandem aldol condensation/1,4‐aza‐Michael addition strategy to achieve highly N 2 ‐selective alkylation of tetrazoles (N 2 /N 1 > 25:1), and the N 2 ‐selectivity was unambiguously confirmed by single‐crystal X‐ray diffraction. Control...