Likun Chen

Transcriptomic profiling of lineage transformation and actionable therapy opportunities in EGFR-mutant non-small cell lung cancer evolving to small cell lung cancer

Abstract Background Neuroendocrine transformation of epidermal growth factor receptor-mutant lung adenocarcinoma (EGFR m LUAD) represents a significant mechanism underlying acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). This histological transformation lacks effec...