Liguo Guo

Mechanism-Driven Risk Assessment of 1,3,6-Tribromocarbazole: An Integrated Strategy Implicates ESR1-Associated Cardiovascular Toxicity

Abstract Polyhalogenated carbazoles (PHCZs) are globally distributed emerging persistent organic pollutants, yet their cardiovascular hazards remain largely uncharacterized. We therefore built an adverse outcome pathway (AOP)-guided prediction-to-validation strategy─coupling envi...