Lidan Liu

STAT3/NF-κB signaling axis in macrophage and myeloid-derived suppressor cell driven immune evasion in lung cancer

Immune checkpoint blockade (ICB) has brought transformative advances to lung cancer management; nevertheless, immunosuppressive tumor microenvironment (TME)-mediated therapeutic resistance constitutes a prominent unsolved bottleneck, mainly originating from the sustained buildup...

Fibroblast-driven matrix remodeling shapes immune exclusion in lung cancer

The lung tumor microenvironment (TME) is shaped by reciprocal interactions among cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), immune cells, endothelial cells, and tumor cells. Available evidence supports an integrated sequence in which tumor-derived factors,...