Li Chen

Augmented enhancement of valproate efficacy by taurine and pyridoxal phosphate via gabaergic metabolic support in epilepsy

A major clinical dilemma in epilepsy treatment lies in the difficulty of balancing efficacy and safety. First-line antiepileptic drugs such as valproic acid (VPA) exhibit dose-dependent side effects. Enhancing γ-aminobutyric acid (GABA)ergic inhibition is a core therapeutic strat...