Leting Huang

Investigating the divergence of β-lactamase PDC variants conferring various antibiotic resistance profiles in Pseudomonas aeruginosa, coupled with the molecular profiling of PDC-266

Pseudomonas aeruginosa is a critical pathogen in hospital-acquired infections, with resistance primarily mediated by chromosomally encoded blaPDC alleles. While wild-type PDCs typically hydrolyze penicillins and cephalosporins, specific amino acid substitutions can broaden their...