Leslie Michels Thompson

iPSC neurodegenerative disease initiative isogenic CAG repeat iPSC line for Huntington's disease

Purpose of Research: in the KOLF2.1J background as an additional disease series within the iPSC Neurodegenerative Disease Initiative (iNDI) collection. Major Findings: KO, were capable of differentiating to striatal and cortical neurons, astrocytes and microglia using established...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...