Leslie Chaltel Lima

In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer

Metastatic cancer remains the leading cause of cancer-related mortality, yet tumor cell–intrinsic mechanisms restraining metastatic dissemination remain incompletely defined. Here, we perform an unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer x...