Leonard Jeffrey Medeiros

Genetic Alterations in Sclerosing Angiomatoid Nodular Transformation of the Spleen

Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign lesion with distinctive morphologic features, but its pathogenesis remains controversial. To clarify its biological nature, we analyzed 24 SANT cases using targeted next-generation sequencing with...

Evaluation of gene expression assays to classify large B-cell lymphoma by molecular subtype using formalin-fixed paraffin-embedded tumor biopsies

Gene expression profiling (GEP) can classify large B-cell lymphoma (LBCL) into activated B-cell (ABC), dark zone signature (DZsig), and germinal center B-cell (GCB) subtypes, which can inform prognosis and treatment strategies. We evaluated the concordance of Clinical Laboratory...

Characterization of the morphological, immunophenotypical and cytogenetic features of high‐grade B‐cell lymphoma with 11q aberration

Aims High‐grade B‐cell lymphoma with 11q aberration is a rare neoplasm of mature B‐cell lineage, and large‐scale clinicopathological studies of this disease remain scarce. To bridge this research gap, we conducted a retrospective analysis of HGBCL with 11q aberration, aiming to e...