Leon J. Schurgers

Matrix Gla Protein is a novel regulator of TGFβ–dependent fibroblast activation and kidney fibrosis

Abstract Kidney fibrosis is the pathologic hallmark of chronic kidney disease (CKD) and is driven by fibroblast-to-myofibroblast transformation (FMT), excessive extracellular matrix accumulation, and persistent activation of transforming growth factor-β (TGFβ) signaling. Although...