Author
Lennart Evers
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Recent research
- Health & MedicineOpen access
PPM1H loss alters intrasynaptic alpha-synuclein localization in a LRRK2-dependent manner
Abstract Mutations in the LRRK2 gene are a major genetic cause of Parkinson’s disease (PD) and induce hyperphosphorylation of RAB GTPases through increased LRRK2 kinase activity. The phosphatase PPM1H counteracts this activity by selectively dephosphorylating LRRK2-phosphorylated...