Lemei Zhu

The immuno-cognitive crossfire: redefining age-related T and B cell dynamics as drivers of neurodegeneration and systemic inflammaging

Aging of the adaptive immune system is not a uniform decline but a patterned reorganization of T and B cell compartments that can drive both systemic inflammaging and neurodegeneration. This review synthesizes emerging evidence that CD8 + CD28− EMRA cells, regulatory T cell insta...