Leila Sarafan Soleimanzadeh

Advancing asparaginase-based therapy for acute lymphoblastic leukemia through computational immunoengineering and molecular dynamics simulations

L-asparaginase is a critical enzyme in the treatment of acute lymphoblastic leukemia (ALL); however, its clinical application is frequently limited by immunogenicity and hypersensitivity reactions. This study utilized a comprehensive computational pipeline that integrated immunoi...