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SIX1 drives acute myeloid leukemia progression by reprogramming glycolytic metabolism and impairing CD8⁺ T-cell effector function

This study aimed to investigate the role of the homeobox gene SIX1 (sine oculis homeobox homolog 1) in acute myeloid leukemia (AML) progression and to explore its underlying metabolic and immunological mechanisms. SIX1 expression was examined in human bone marrow stromal cells (H...