Lei Diao

Naphthalimide-based andrographolide nanoplatform suppresses ccRCC via targeting the HIF-2α/VEGF signaling axis

Constitutive activation of hypoxia-inducible factor-2α (HIF-2α) is a central oncogenic driver in clear cell renal cell carcinoma (ccRCC). In this work, a naphthalimide-based multifunctional nanoplatform was developed as a drug delivery system for andrographolide (AG) to improve i...