Lee A. Gethings

Multi-reflecting time-of-flight mass spectrometry enables high-accuracy metabolite identification in a demonstration study using serum samples from COVID-19 patients

Abstract Introduction Accurate metabolite identification remains a major challenge in untargeted metabolomics due to overlapping signals, isomeric compounds, and insufficient mass resolution. The multi-reflecting time-of-flight (MRT) platform provides mass resolution exceeding 20...

Advances in the Design and Functionality of a Compact Multi‐Reflecting Time‐of‐Flight Mass Spectrometer

RATIONALE: High-resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications demand instrumentation to be capable of combining sub-ppm mass accuracy, high resolving power, rapid f...