Leah M. Seebald

Creating NewAccess Points for Strategic SynthaseEngineering: Ethane Thioester Analogs as Truncated Coenzyme A BuildingBlocks Unlock Expanded Acyl Carrier Protein Loading Capabilities

Abstract Strategic engineering of natural product biosynthetic pathways through the incorporation of alternative, tunable carbon-based building blocks represents a promising approach for accessing medicinally relevant molecules. However, efforts toward this goal have been hindere...