Leah H. Rubin

Kynurenine Pathway Activation is Associated with Poor Sleep Efficiency in Men With HIV

Background: Sleep disturbances are common in people with HIV, yet the underlying biological mechanisms remain poorly understood. Chronic immune activation in HIV can induce the tryptophan-kynurenine (TK) pathway, which both reduces melatonin synthesis and increases production of...

Distinct acute and chronic brain health phenotypes among people living with HIV in a Ugandan clinical cohort: a comorbidity network analysis

Background: Individual brain health conditions among people living with HIV in sub-Saharan Africa are increasingly well documented, but the co-occurrence of comorbidity and multimorbidity across distinct neurological and psychiatric conditions remains poorly characterized in this...