Le-le Chang

Multi-omics profiling reveals PIK3CA -driven immunometabolic reprogramming in cervical cancer

The PIK3CA mutation is a prevalent driver in cervical cancer, but its role in orchestrating a coordinated remodeling of transcriptional, translational, and metabolic networks is poorly understood. We introduced the PIK3CA-E545K mutation into cervical cancer U14 cells via CRISPR/C...