Laurel Patterson

Computational modeling of motor-driven extension of microtubule bundles in axons reveals a biphasic effect of crosslinker density

In addition to actin assembly at the growth cone, neuronal axons elongate via interactions between microtubules, dynein motor proteins and cross-linking proteins. Dynein translocates microtubules toward the growth cone and exerts extensile forces for axonal outgrowth. During this...