Laura K. Hilton

Evaluation of gene expression assays to classify large B-cell lymphoma by molecular subtype using formalin-fixed paraffin-embedded tumor biopsies

Gene expression profiling (GEP) can classify large B-cell lymphoma (LBCL) into activated B-cell (ABC), dark zone signature (DZsig), and germinal center B-cell (GCB) subtypes, which can inform prognosis and treatment strategies. We evaluated the concordance of Clinical Laboratory...

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...