Laura Elizabeth Downie

Understanding higher‐order aberrations in keratoconus

ABSTRACT Keratoconus is characterized by progressive thinning and increasing irregularity of the cornea, leading to substantial degradation in optical quality through the induction of both lower‐ and higher‐order aberrations (HOAs). In addition to inducing myopic and astigmatic r...

The effect of 0.1% topical ciclosporin a for 12-weeks on the ocular surface innate and adaptive immune response in dry eye disease: protocol for a randomized controlled clinical trial

Background Ocular surface immune cells and pro-inflammatory cytokines have been reported to be increased in Dry eye disease (DED). Immunosuppressive agents such as topical cyclosporine A (CsA) can inhibit dendritic cell and T cell activation. However, CsA’s impact on ocular surfa...