Laura De Laporte

Cell-derived lactate triggers local hydrogelation and phenotype remodelling

Abstract Many tumours release lactate as a major metabolic product and signalling molecule. Here we use lactate flux as an endogenous trigger for covalent hydrogel formation. Phenol-functionalised alginate remains soluble until cell-derived lactate is oxidised by lactate oxidase;...

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Organoid research holds tremendous potential for personalized medicine and drug development. However, current limitations include reproducibility issues largely due to the use of biologically derived materials, which are prone to batch-to-batch variations. Here, we report a chemi...