Latifa Kazzazy

A bacterial protein inhibitor of dUTPase disrupts zebrafish embryogenesis through a conserved active‐site mechanism

Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein in...