Lars J. W. van Beurden

Human Hsp70 paralogs display selective J-domain interactions tuning proteostasis under stress

Hsp70 chaperones are central regulators of proteostasis, mediating folding, refolding, degradation, and aggregation-prevention. Their activity is tuned by the diverse J-domain proteins (JDPs), which both recruit client proteins and stimulate Hsp70 ATP hydrolysis via interaction w...