Lara C. Busby

Reciprocal coupling between EMT and BMP morphogen signalling drives collective cell invasion

Abstract During collective cell invasion, epithelial-to-mesenchymal transition (EMT) and morphogen signalling-mediated cell fate specification are traditionally viewed as a linear cascade: morphogens drive cell fates that activate EMT gene expression programs. Here, we uncover re...

Ectomesenchymal identity emerges via relief of Twist1 transcript destabilisation

Abstract During vertebrate development, a subset of cranial neural crest cells (CNCCs) termed ‘ectomesenchyme’ differentiates into cell types canonically associated with the mesoderm (cartilage, bone and muscle). While the molecular decisions that guide CNCCs toward ectomesenchym...