Lang Du

Disclosing Structural Determinants Governing Stereopreferences of Ketoreductases toward Reduction of Halogenated Aryl Ketones

Abstract Ketoreductases (KREDs) are widely used for asymmetric ketone reduction, yet predictable control of stereoselectivity remains challenging due to the limited understanding of structure–selectivity relationships. Here, we integrate site-directed mutagenesis and molecular dy...