Lang Du

Shifting from Systemic Absorption to Local Interactions: The Bidirectional Role of Gut Microbiota in Curcumin’s Health Benefits

Curcumin, a natural polyphenol, has garnered considerable attention owing to the paradox between its low oral bioavailability and reported pharmacological effects. Traditional paradigms centered on systemic absorption and plasma exposure may not fully explain its broad actions in...

Disclosing Structural Determinants Governing Stereopreferences of Ketoreductases toward Reduction of Halogenated Aryl Ketones

Abstract Ketoreductases (KREDs) are widely used for asymmetric ketone reduction, yet predictable control of stereoselectivity remains challenging due to the limited understanding of structure–selectivity relationships. Here, we integrate site-directed mutagenesis and molecular dy...