Lai Wang

Lactate suppresses T follicular helper cells in lupus in association with metabolic-epigenetic reprogramming

Aberrant CD4⁺ T cell differentiation, particularly the expansion of T follicular helper (Tfh) cells, is a hallmark of systemic lupus erythematosus (SLE) and is critically dependent on metabolic reprogramming. Although altered lactate metabolism has been implicated in autoimmune d...