Lacy M. Alexander

Evidence for an inflammatory contribution to cutaneous microvascular endothelial dysfunction in non-Hispanic Black women

Non-Hispanic Black (NHB) adults demonstrate impaired microvascular endothelial function, characterized as reduced nitric oxide (NO)-mediated vasodilation, compared to non-Hispanic White adults. A sexual dimorphism exists, where microvascular dysfunction in NHB men is mediated thr...

Methods for analyzing acetylcholine-induced vasodilation in human skin

Intradermal microdialysis, combined with laser‑Doppler flowmetry and local heating, is commonly used to investigate mechanisms of endothelial function and dysfunction in the cutaneous microcirculation. Local perfusion of acetylcholine (ACh), with and without N G ‑nitro‑L‑arginine...