L F Tempest

Scientific perspectives on in vivo developmental neurotoxicity testing: study design, regulatory context, and future directions

Developmental neurotoxicity (DNT) potential of (agro)chemicals is assessed in rodents according to OECD Test Guidelines (TG) 426 (DNT) or 443 (Extended One-Generation Reproductive Toxicity; EOGRTS) incorporating a DNT cohort. While the EOGRTS evaluates reproductive and neurotoxic...