Kyla Manja

Brown adipose tissue ankyrin-B cell-autonomously modulates lipid content and its deletion protects male mice against diet-induced obesity

Fatty acid (FA) availability for brown adipose tissue (BAT) thermogenesis depends in part on lipolysis of lipid droplet (LD) triglycerides. Here, we identify the membrane adaptor ankyrin-B (AnkB), encoded by the cardiometabolic disease-associated ANK2 gene, as a regulator of brow...